您好，
訪客
登錄/注冊
摘 要：目的 利用稻萃誥蚣際跆剿鞴檳山良鐸教授治療肺部結節用藥特點及方劑配伍規律。方法 收集2010年1月～2020年7月姜良鐸教授治療肺部結節病的有效病例方劑238首錄入數據庫，采用R語言及Python語言作為數據挖掘工具，對用藥及性味歸經等數據進行關聯性研究，通過層次聚類挖掘核心處方。結果 篩選處方238首，分析確定藥物使用頻次、藥物之間的關聯規則，用藥頻率>40%的中藥有10味，常用的藥物關聯組合為1個核心藥物加2組藥物，處方以苦味藥為主，以肝經作為主要歸經的關聯用藥規律。聚類得出核心處方為黃芩加葛根湯去甘草加石膏、枳實、枳殼，并常輔以活血化瘀、清熱化痰、軟堅散結之藥。結論 姜良鐸教授在肺部結節的治療過程中，方劑配伍常以理氣活血、軟堅散結、清熱化痰等中藥組合為主，重視肝、脾、大腸、心、胃等與肺的關聯，喜用辛苦、苦溫、甘寒之藥。
關鍵詞：肺部結節;方藥規律;R語言;關聯分析;層次聚類
中圖分類號：R249 文獻標識碼：A 文章編號：1009-8011（2022）-6-000-05
Discussion on Medication Rules of Professor Jiang Liangduo’s Formulas for Pulmonary Nodules Based on Data Mining
LIU Juan1 GUO Zhou2 XUE Dan1*
?。?.Prevention and Treatment Center， Dongzhimen Hospital， Beijing University of Chinese Medicine， Beijing 100700， China;
2.Department of Internal Medicine， Changping District Hospital of Integrated Traditional Chinese and Western Medicine， Beijing 102208， China）
Abstract：Objective To analyze Professor Jiang Liangduo’s medication characteristics and prescription compatibility in the treatment of pulmonary nodules. Methods The effective prescriptions of Professor Jiang Liangduo in the treatment of pulmonary sarcoidosis were collected and entered into the database. R language and python language were used as data mining tools to study the correlation between the data of herbsuse， sex， taste and meridian tropism. Results 238 prescriptions were screened， and the frequency of herbs use and the association rules between herbs were analyzed and determined. There were 10 kinds of traditional Chinese medicine with more than 40% frequency in herbs use. The commonly herbs-associated combination consisted of one core herb and two other groups. The main prescription was bitter herbs， and the main channel was liver. Cluster analysis showed that the core prescription was Scutellaria plus Gegen decoction， minus licorice plus gypsum， Fructus aurantii， Fructus aurantii， often with herbs of promoting blood circulation and removing blood stasis， clearing heat and resolving phlegm， softening hard and dispersing knot. Conclusion In the treatment of pulmonary nodules， Professor Jiang Liangduo’s prescriptions are mainly composed of traditional Chinese medicine， such as regulating qi and activating blood circulation， softening hard and dispersing knot， clearing heat and resolving phlegm. Great importance was attached to the relationship between liver， spleen， large intestine， heart， stomach and lung， and likes to use hard， bitter， warm and sweet cold medicines.
nlc202204021134
